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The level of caffeine in the blood may help diagnose Parkinson's disease

Testing your blood caffeine level may provide a simple way to help diagnose Parkinson's disease.
Parkinson's diagnosis reasearch
Parkinson's and Caffeine
A study found that people with Parkinson's disease had significantly lower levels of caffeine in their blood than people without the disease. Even if they consume the same amount of caffeine.

  • "Previous studies have shown a correlation between caffeine and a lower risk of Parkinson's disease," said study researcher Shinji Saiki of the University of Jundendo in Japan. But we didn't know much about how caffeine is metabolized in people with the disease."
  • People in more severe stages of the disease did not have lower levels of caffeine in the blood. Suggesting that the decline occurs from the early stages of the disease, according to David J. Munoz of the University of Toronto, Canada.


“If these results can be confirmed, they suggest an easy test for early diagnosis of Parkinson, perhaps even before symptoms appear,” Munoz said. This is important because Parkinson's disease is difficult to diagnose, especially in the early stages. ”

The study included 108 people with Parkinson's disease and 31 people of the same age who did not have the disease. Their blood was tested for caffeine. It has also been tested for mutations in genes that can affect caffeine metabolism.
Both groups consumed the same amount of caffeine, an average of about two cups of coffee a day. But people with Parkinson's disease had significantly lower blood levels of caffeine.
In statistical analysis, researchers found that the test can be used to reliably identify people with Parkinson's disease, with a score of 0.98 where a score of 1 means that all cases are correctly identified.
In the genetic analysis, there were no differences in caffeine-related genes between the two groups.

Full Study:
Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease
Motoki Fujimaki, Shinji Saiki, Yuanzhe Li, Naoko Kaga, Hikari Taka, Taku Hatano, Kei-Ichi Ishikawa, Yutaka Oji, Akio Mori, AyamiOkuzumi, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi, Takashi Ueno, Yoshiki Miura, Yoshiki Miura, , Nobutaka Hattori

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